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There were no statistically significant interactions by treatment and background medication subgroup for change in HbA 1c or body weight except for change in HbA 1c (background insulin vs insulin plus metformin) in PIONEER 8 ( p = 0.0408)

During the initial double-blind phase (Part 1), participants were expected to refrain from initiating symptomatic PD therapy

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In the pancreas, GLP-1 stimulates insulin release only when blood glucose is elevated, creating a glucose-dependent safety mechanism that prevents dangerous low blood sugar episodes