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Indeed, the balance between saturated (SFA), mono (MUFA), and polyunsaturated FA (PUFA) is essential for cellular homeostasis and biological functions (Dyall et al, 2022)

Five imputed datasets were created, and the results were pooled using Rubins Rules 30

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In response to OS, different metabolites oxidize highly reactive cysteine residues in KEAP1, inducing a conformational change in the KEAP1-NEDD8-CUL3-RBX1-E3 ubiquitin ligase complex, with an improper orientation of Lys residues on NRF2 [122, 158]