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Besides, this study provided insights into the mechanistic targets through which these agents exerted their beneficial actions, with highlighting the role of HMGB1/RAGE/JAK-2/STAT-3, PI3K/AKT/CREB/BDNF/TrkB, AMPK/SIRT-1/m-TOR, and PERK/CHOP/Bcl-2 cues, as possible contributors in ADHDs pathophysiology