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Molecular docking studies have revealed that T80 interacts with apolipoprotein E through interactions and hydrogen bonding, which may be the mechanism for its transmembrane permeation across the BBB 47

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Due to the increased amount of adipose tissue, obese patients are more predisposed to systemic inflammation with higher levels of pro-inflammatory cytokines, such as interleukin 6, eotaxin-1, TNF-, transforming growth factor beta 1 (TGF-1) and CRP

The gold standard to evaluate the ability of antioxidant inhalation to protect against air pollution would be to conduct controlled studies in environmental exposure chambers with human subjects