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Ex-4c stimulates GLP-1Rs to directly activate arcuate POMC neurons While POMC neurons are present in both the nucleus tractus solitarius (NTS) and the ARH, previous studies have shown that NTS POMC neurons do not express GLP-1Rs [15]

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Losa and colleagues have now shown that where this paradoxical response is seen, in approximately a third of patients, recurrence after surgery is very infrequent compared to patients not showing the paradoxical response, Grossman says