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The substance was discovered and identified in the year 1866 by the German chemist Karl Heinrich Ritthausen, who treated wheat gluten (for which it was named) with sulfuric acid

Khan et al., 2019

The immune response mounted to allergens causes a variety of symptoms that occur because of the rapid release of inflammatory mediators, especially histamine, depending on how much is released and where [1]

They now include many proteins that are known ASO binders but were not detected or not significantly enriched with Drug-ID before, such as XRCC5/6 and HSP90AA1/B1 (Extended Data Fig

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