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GLP-1 plays a crucial role in glucose homeostasis by stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppressing glucagon release, and slowing gastric emptying

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Weight loss naturally reduces total body water content, improved glycemic control in diabetic patients may reduce osmotic diuresis from glucosuria, and gastrointestinal side effects can temporarily affect hydration status

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Because Ozempic slows down stomach emptying, you may still have food and acid in your stomach hours after your last meal, making nighttime reflux more likely

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