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5 In addition to cosmetic uses, glutathione has been studied for topical application for systemic use as well, especially in the context of management of autism spectrum disorder (ASD)

Scientific reports , 14 (1), 21527

There is no strong clinical evidence showing it can safely or effectively treat opioid withdrawal

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A separate question is whether abnormalities in glutamate are a fundamental cause of OCD, or whether they are a downstream consequence of other processes that are more primary to the pathophysiology