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[18] [19] For healthcare professionals prescribing tirzepatide and patients taking this medication, proactive monitoring and management of cardiovascular parameters is recommended , particularly during treatment initiation and dose escalation

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The peptide's long-lasting effects come from attaching a C-18 or C-20 fatty acid side chain through a glutamic acid gap

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Despite significant improvement with completion of a prednisone taper, the rash recurred