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Notably, 1,568 transcripts were uniquely regulated in response to GLP-1MK-801 treatment, emphasizing that coordinated activity between the two receptor targets in vivo potently influences hypothalamic transcription

Nat Rev Cardiol 10(9):531547 Verdonschot JAJ, Hazebroek MR, Derks KWJ, Barandiarn Aizpurua A, Merken JJ, Wang P, Bierau J, van den Wijngaard A, Schalla SM, Abdul Hamid MA, van Bilsen M, van Empel VPM, Knackstedt C, Brunner-La Rocca HP, Brunner HG, Krapels IPC, Heymans SRB (2018) Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-term life-threatening arrhythmias

Influence of oncometabolites in CSC phenotype Even if the impact of oncometabolites in the crosstalk between stromal cells and PC cells has been reasonably assessed, less clear is which are the oncometabolites responsible for maintaining the metabolic properties of CSCs

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Inflammation and immune modulation Chronic inflammation and immune dysregulation are central to the pathogenesis and progression of MASLD, 115 particularly during the transition from simple steatosis to MASH