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Journal of Applied Microbiology, 110(1), pp.147-155

Whats next: Advanced analytics for a new era of medicine GLP-1 receptor agonists are more than just the latest metabolic blockbuster

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Under homeostatic conditions, the ECs maintain the integrity of blood vessels, modulate blood flow, deliver nutrients to the underlying tissues, regulate fibrinolysis and coagulation, control platelet adherence and patrol the trafficking of leukocytes (Figure 2A) (Figure 2B) ( Figure 2 According to the epidemiological studies, diabetes mellitus is considered as one of the main risk factors for CVD (Figure 1) ( Diseases such as T2DM that induce high levels of vascular injury are accompanied by an elevated number of circulating endothelial cells (CECs) (Figure 2C) ( Macroangiopathies, by inducing atherosclerosis in the coronary, carotid, and peripheral arteries, increase the risk of myocardial infarction (MI), stroke and peripheral artery disease (PAD)

L-carnitine also ameliorates oxidative stress by reducing ROS production (43, 47, 75), decreasing hepatic malondialdehyde (MDA) content (30, 59, 76), lowering 8-OHdG concentrations, and attenuating 4-hydroxynonenal (4-HNE) immunostaining intensity (45)

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