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In healthy controls, elevated GLP-1 plasma levels after administration of the Dipeptidyl peptidase-4 inhibitor vildagliptin, were associated with impaired gastric accommodation ( Peptide YY (PYY) PYY is a gut hormone secreted from endocrine L-cells in the gut mucosa, most prominently present in the ileum and the colon, and released into the circulation after ingestion of food (109)

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10.1152/ajplung.00128.2016 2 BaekJ.AfshinniaF.MichailidisG.PennathurS

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Thus, as circulating L-carnitine concentration increases (as after high-dose intravenous or oral administration of L-carnitine), efficiency of reabsorption decreases and clearance increases, resulting in rapid decline of circulating L-carnitine concentration to baseline