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The full molecule activates melanocortin receptors particularly MC1R and MC3R triggering a cascade of downstream effects

Moreover, the release of these toxins and enzymes stimulates the production of pro-inflammatory cytokines, such as TNF-, IL-1, and IL-6

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Declarations Conflict of Interest Linda Stein Gold is an investigator/advisor and/or speaker for AbbVie, Amgen, Arctis, Bristol Myers Squibb, Dermavant, Eli Lilly, Janssen, Novartis, Pfizer, and UCB