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Asp can form a cyclic imide intermediate that either regenerates the original amino acid or converts to iso-aspartate, an isomer with different properties

Although corticosteroids and biologics have shown clinical benefits, their long-term use is often constrained by high costs, adverse effects, heterogeneous patient responses, and limited applicability across AD subtypes

PMID: 15 LiJHuangQSunSZhouKWangXPanKet al

Impact of maternal cigarette smoke exposure on brain and kidney health outcomes in female offspring