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Within a 68-page briefing document for the committee meeting, the FDAs own experts wrote that there is a lack of evidence to make a conclusion on the effectiveness of BPC-157 for treating ulcerative colitis and there already are FDA-approved drugs available to treat ulcerative colitis, and they proposed not adding BPC-157 to the 503A Bulks List

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J Pharmacol Exp Ther 1993

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In contrast, phosphorylation of the RNA Polymerase II (RNAPII) C-terminal domain (CTD) on serine 2, 5 and 7 (Ser2, Ser5 and Ser7) were reduced gradually and less specifically, as expected upon constitutive splicing inhibition 8,73 (Fig