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In a 4-week, placebo-controlled trial of VYVANSE in pediatric patients ages 6 to 12 years old with ADHD, there was a dose-related decrease in weight in the VYVANSE groups compared to weight gain in the placebo group

De novo lipogenesis: Dysregulation in the acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase-1 resulted in hepatic steatosis and hypertriglyceridemia (Hong et al

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Primary Weight-Loss Outcomes The headline results were remarkable