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Consumption of high-calorie, high-sugar and high-fat foods is conducive to the development and maintenance of obesity ( FIGURE 6 5 Application of GLP-1RAs in T2DM GLP-1RAs can be divided into two categories: animal GLP-1 and its derivatives and human GLP-1 and its derivatives, which has experienced a development process from short-acting to long-acting to ultra-long-acting (Zhao et al., 2021

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Acute pancreatitis has been reported in association with GLP-1 receptor agonists, though a definitive causal relationship remains under investigation

However, when it is in excess, these benefits are overcome by a pro-inflammatory activity, being associated with worse haemodynamic and metabolic profile in patients affected by HFpEF [35, 36]

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