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Tolerance development - Some individuals find that appetite suppression diminishes over time, requiring dose adjustments or additional strategies Maintenance is a separate challenge - Many people regain weight after discontinuing GLP-1 medications

hydrates fast and tastes greatbut the sugar content can be a red flag for many GLP-1 users

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Semaglutide also carries a warning about potential worsening of diabetic retinopathy complications, particularly in patients with pre-existing retinopathy

To investigate the underlying mechanism of these behavioral improvements, we analyzed astrocytic GABA and electrophysiological changes

Shalaby, M., Abdelaziz, R