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PMID: 30093705

Conclusion and future perspectives New knowledge about the pathophysiology of NAFLD has been accumulating over the last decade, displaying the complexity of the mechanisms involved in the development of this condition

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Another study reported that TLR4 mutant mice fed HFD showed neurovascular protection by improving astrocytic vascular recovery and cerebromicroenvironement [143]

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The agency cited immunogenicity risks (peptides can trigger anti-drug antibodies with repeated injection), manufacturing impurity concerns (endotoxin contamination, truncated sequences, diastereomers), and the absence of robust human clinical data for most compounds