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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

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| 06.16.26 | 8 min read

These mechanisms explain why peptides are studied for their potential to shorten the inflammatory phase of knee healing

These can include minor discomfort, redness at the injection site, or mild digestive symptoms

Critically, the attenuation of stress via FAAH inhibition does not appear to impair the ability of FAAH inhibition to facilitate extinction memory [19]