Furthermore, also in rats, pea protein and pea-protein hydrolysate have been shown to similarly stimulate GLP-1 release, although the hydrolysate showed stronger eating-inhibitory properties (Reference Hberer, Tasker and Foltz66) (total energy intake: 63 (SEM 6) kJ, 46 (SEM 3) kJ, 67 (SEM 5) kJ after pea protein, the hydrolysate and the control, respectively)
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Although both doses similarly improved fasting and the initial postprandial glycemia, only liraglutide 3.0 mg improved the 5-h incremental glucose response in this population
GLP-1s like Wegovy are resistant to DPP-4, and their levels remain elevated in the bloodstream for 4-7 days
Persistent tachycardia (heart rate consistently above 100 bpm at rest) warrants clinical evaluation
It is also worth noting that in this patient population, lipid-lowering therapy may be difficult due to elevated creatine kinase (CK) activity