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Antitumor effects of PRIMA-1 and PRIMA-1(Met) (APR246) in hematological malignancies: still a mutant P53-dependent affair

As a major intracellular antioxidant, it directly neutralises reactive oxygen species (ROS) and free radicals that accumulate during normal metabolism and are elevated in fatty liver disease

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Deamidation Deamidation occurs when asparagine (Asn) or glutamine (Gln) residues in the peptide chain lose their amide group and convert to aspartic acid or glutamic acid respectively

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