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Monitoring and adjustment during the first 12 weeks What to track: Weight: Weekly weigh-ins at the same time of day (morning, after bathroom, before eating)

Change in viral load, measured in plasma, is sometimes used as a surrogate marker in disease progression

Overall, at baseline, 26.9% of patients did not have established cardiovascular (CV) disease, while 73.1% had established CV disease

Tetrodotoxin-sensitive release of amino acids

In addition, 355 of 652 (54.5%) persistent individuals achieved HbA1c values 7.0%, whereas 159 of 333 (47.8%) non-persistent individuals reached HbA1c levels 7.0%