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The direct comparison upon using the same concentration of ruthenium of the molecular agent Ru(II)-OH and NP4 showed a significantly higher tumor accumulation of the nanoparticle formulation NP4 (Supplementary Fig

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In neurons, the cyclic adenosine 3,5-monophosphate (cAMP)-cAMP-dependent protein kinase (PKA)-cAMP response element-binding protein (CREB) signaling pathway is implicated in synaptic plasticity and cognitive function, and is regulated by the UPS through degradation of the regulatory subunit of PKA (Vitolo et al., 2002)

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Current therapeutic development focuses on either recombinant protein formulations (Jocasta Neurosciences JN-0413) or mRNA-based approaches to stimulate endogenous production (Klothea Bio)