Hwang, N.R., et al., Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions
This endogenous protective mechanism primarily inhibits oxygen radical generation by upregulating antioxidant factors such as HO-1, thereby mitigating oxidative stress
Negative evidence: A study in Indonesian individuals showed that supplementation with glutathione combined with vitamin C, alpha-lipoic acid, and zinc did not significantly lighten skin compared to placebo (Sitohang et al., J Clin Aesthet Dermatol, 2021) [63]
DEFEND YOUR CELLULAR HEALTH & LONGEVITY
Changes in the ascorbate metabolism of apoplastic and symplastic spaces are associated with cell differentiation
Moreover, disruption of autophagy-related genes such as Atg5 and Atg7 also suppresses Erastin-induced ferroptosis, indicating the involvement of autophagy-dependent mechanisms in this process (Green, 2019)