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Early intervention can significantly improve outcomes and prevent the condition from worsening
"Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency"
[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%
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