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When PI3K and its regulatory proteins, p85 and p110, are recruited by IRS, they will further recruit and activate PDK1 (PIP 3 -dependent kinase 1), Akt (PKB), mTORC2, S6 kinases and PKC

This process could be inhibited by 4-phenylbutyric acid (4-PBA) (64)

Ezaki S, Suzuki K, Kurishima C, Miura M, Weilin W, Hoshi R, et al

Somatostatin secretion is not regulated by insulin in perfused mouse pancreases To test the paracrine effect of insulin signalling on somatostatin secretion, we initially infused different concentrations of insulin to perfused mouse pancreases

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