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Investigating the pro-cognitive and anti-depressant efficacy of metformin: a systematic review and meta-analysis of randomised controlled trials

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23 March 2017 Scientific Reports 7: Article number: 40815

leakage from testicular mitochondria has been emphasised by the finding that the mRNA for this enzyme is markedly higher in the testes than the liver, unlike GPx and catalase.13 Moreover, SOD-2 mRNA levels are developmentally and translationally regulated with maximal levels of expression in early post-meiotic germ cells.13 Although catalase is of limited importance in the testes, there are several isoforms of GPx in this tissue that use glutathione (GSH) as a source of electrons to reduce H 2 O 2 to water