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52 In a large meta-analysis by Chiang et al involving 106,395 participants and 55 RCTs, GLP-1 RA therapy was associated with an increased risk of gastroesophageal reflux disease (GERD) compared to placebo, with a reported relative risk of 2.19 (95% CI: 1.483.25)

[46] Among black garden ants ( Lasius niger ), the lifespan of queens is an order of magnitude greater than of workers despite no systematic nucleotide sequence difference between them

It is also involved in immune regulation, helping to maintain the redox state of immune cells and influencing cellular signalling pathways

Why this study matters: SURMOUNT-MAINTAIN randomized adults after 60 weeks of tirzepatide to continue maximum dose, reduce to 5 mg, or switch to placebo for 52 weeks

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This location allows most patients to self-inject with minimal difficulty and provides excellent visibility for proper technique