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As research has progressed, it has been revealed that vagal sensory neurons distributed in the intestinal and hepatic portal regions play a crucial role in sensing circulating GLP-1 and mediating its physiological actions

Women who follow vegan or vegetarian diets, have digestive issues (like Crohns or celiac disease), or have had weight-loss surgery may struggle to absorb enough B12 from food

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Smoking, antipsychotic metabolic effects, inflammation, poor diet, substance use and copper-zinc imbalance may increase mitochondrial stress

A thorough medical evaluation is necessary before beginning therapy