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The Alzheimers prevention initiative generation program: study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimers disease

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2004;43 Suppl 2:II7-II46

doi:10.1001/jama.2020.1012

Moreover, A double-blind study of patients with T2DM treated with metformin led to significant changes in the relative abundance of more than 80 bacterial species compared with placebo after 4 months, in which an increase in Escherichia and Akkermansia muciniphila and a decrease in Intestinibacter were also observed, whereas most of the changes with placebo occurred in phylum Firmicutes and phylum Proteobacteria (Wu et al., 2017)