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Lets say that your target protein is smaller than GST, such that most of the size of the GST-fusion protein will be contributed from GST and not your target protein

Masubuchi Y, Sugiyama S, Horie T

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Cellular senescence in kidney fibrosis: pathologic significance and therapeutic strategies

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Its mechanism involves activating the AMPK/SIRT1 pathways and suppressing lipogenic regulators like PPAR and SREBP-1c, highlighting its potential as a therapeutic candidate for NAFLD (96)