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The NRF2 protein isoforms encoded by these splice variants lack the KEAP1 interaction domain, thus preventing NRF2 degradation and resulting in protein stabilization and transcription of NRF2 target genes [183]

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Avoid folic acid-blocking drugs such as birth control or methotrexate

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Your GP can provide personalised advice on lifestyle modification, optimise management of diabetes, blood pressure, and cholesterol, arrange appropriate monitoring, and coordinate care with specialists when necessary