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In antioxidant research, GSH acts as a direct free radical scavenger and is an essential cofactor for glutathione peroxidases (GPx enzymes), which detoxify hydrogen peroxide and lipid hydroperoxides

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Advanced molecular studies reveal that FOXO4-DRI promotes p53 nuclear exclusion and subsequent mitochondrial targeting, where p53 interacts with BCL-2 family proteins to promote mitochondrial outer membrane permeabilization and cytochrome c release

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