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Several drug-activated nuclear receptors including constitutive androgen receptor (CAR) and pregnane X-receptor (PXR) recognize drug responsive elements within the 5 flanking promoter region of CYP2C genes to mediate the transcriptional up-regulation of these genes in response to xenobiotics and steroids (19)

Post-training, we calibrated each model output to age units by rescaling predictions to match the mean and standard deviation of chronological age

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This is the medical term for the slowing of the rate at which food and medicine move from your stomach into your small intestine

This designation allows use only for in vitro laboratory testing and experimentation to support scientific research while being compliant with regulations

[Google Scholar] Berndt, C., Christ, L., Rouhier, N., Mhlenhoff, U., 2021