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As with other GLP-1-based therapies, the most frequently reported side effects of retatrutide particularly during the initiation and dose-escalation phases are gastrointestinal in nature
Endogenous GLP-1 has a short plasma half-life of about 2-3 min (46)
Statistical analysis Data were analysed using the GraphPad Prism version 7 (GraphPad Software) with the exception of the analysis of RNA-sequencing data, which is described in the Materials and Methods section under RNA-sequencing data analysis
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