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raise concerns about B12 degradation from multivitamins in solution, their experiments cant be extrapolated to human digestion in which B12 transport proteins protect B12 and select active B12 over inactive analogs

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The first study (ALA in Diabetic Neuropathy Study) enrolled 328 patients with symptomatic peripheral neuropathy and non-insulin-dependent diabetes mellitus who were randomized to receive an intravenous infusion of ALA at three different doses (1200 mg, 600 mg, or 100 mg/day) or a placebo for a period of 3 weeks