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The authors highlight three urgent priorities: Reframing GLP1 receptor agonists as essential medicines to reduce multimorbidity and premature mortality Addressing inequitable access and affordability, particularly in low and middleincome countries Strengthening healthsystem capacity, alongside prevention and behavioural support, to deliver safe and effective obesity care As the paper makes clear, prevention and treatment are codependent, stigma remains a major barrier, and lessons from HIV show what is possible when access, advocacy and systems change move together.

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Finally, transmission electron microscopy revealed that SLC25A39 knockout caused severe mitochondrial structural damage, characterized by loss or reduction of mitochondrial cristae in LUAD cells (Fig

[DOI] [PubMed] [Google Scholar] 68.Koski KG, Scott ME