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In summary, there are several factors that can influence gut microbiota composition which impacts the microbial-derived metabolites that enter circulation, and these metabolites in circulation or lack of metabolites directly interact and influence BBB physiology (Fig

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Calkin C, McClelland C, Cairns K, Kamintsky L, Friedman A

Over time, this chemical irritation may alter how local nerves process pain, increasing sensitivity so that ordinary pressure triggers significant discomfort