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If It Is a Diabetes Drug, How Can Retatrutide Help with Weight Loss

The analysis included older weight loss drugs as well as newer GLP-1 drugs, including Wegovy (semaglutide) and Zepbound (tirzepatide)

We found that administering 80-nM GLP-1 significantly counteracted the inhibitory effect of pasireotide on high glucose (20 mM)-induced insulin production, aligning with the cAMP levels in GLP-1R-MIN-6 cells

This isn't a smooth ride but the fundamentals support the upward trajectory

doi: 10.1016/j.psyneuen.2019.05.026 24 LeachmanJRCincinelliCAhmedNDalmassoCXuMGatineauEet al

in clinical use, the best-known GIP-related medication is tirzepatide, sold as Mounjaro for type 2 diabetes and Zepbound for weight management, and it is called a dual GIP/GLP-1 receptor agonist because it acts on both pathways