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Meanwhile, organic anion transporter (OATP), also found in the hepatocyte basement membrane, handles the uptake of unconjugated BAs

These rates appear to be higher than those reported in clinical trials, for example, 22.6% of patients prematurely discontinued therapy during the 24-month trial period in the SUSTAIN 6 trial of semaglutide [37], and 27.6% of randomised patients prematurely discontinued albiglutide during the 25-month trial period in the HARMONY trial [86]

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However, the physical sensation of appetite suppression varies based on the standard dosing schedule

The Future of GLP-1 and Personalised Dosing Pursuing such a strategy represents a coming together of two major pharmaceutical trends in personalised medicine and GLP-1 treatments