GLP-1 signaling reduces appetite and modulates reward, while GIP signaling enhances metabolic regulation and may have central nervous system effects
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Gradual, well-supported weight loss combined with adequate protein intake, sufficient calcium and vitamin D, and regular resistance and weight-bearing exercise can help preserve both muscle mass and bone strength while using GLP-1 medications
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By binding to GLP-1 receptors in the pancreas, brain, and gastrointestinal tract, they enhance insulin secretion, suppress glucagon release, and promote satiety
The main characteristics of the studies included are summarized in Supplementary Table 2
