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When we talk about inflammation, honestly it's a big general term, but you're talking about, when you're talking about serotonin release at the level of neurons, we know that these inflammatory molecules cross the blood-brain barrier

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Moreover, Tet3-KD neurons or Tetrodotoxin-induced decreases in Tet3 expression exhibited increased CpG methylation at the BDNF promoter IV region, whereas bicuculline-induced increases in Tet3 expression were shown to be associated with decreased methylation at the same region, supporting a pivotal role of Tet3 in regulating gene expression in response to global synaptic activity changes [54]