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The precise etiopathology of CD is still unknown, but oxidative stress is widely acknowledged to play a critical role in the diseases pathogenesis

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It has been shown that the cytosolic APX imparts cross compartment protection of the other sub-cellular organellar APXs like mitochondrial APX, thylakoidal and stromal APXs hinting toward the fact that cytosolic AsA-GSH pathway plays an important role in protecting the other organelles during periods of stress (Davletova et al., 2005)

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DOI: 10.1016/j.freeradbiomed.2017.08.014 99

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