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32 The SOUL trial evaluated oral semaglutide in patients with T2D who had established atherosclerotic cardiovascular disease, chronic kidney disease (CKD), or both

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Assumptions due to missing data are stated explicitly where usedmost importantly that menopausal status, baseline vulvovaginal symptoms, sexual activity, contraceptive use, and co-medications are frequently unreported in pharmacovigilance and trial summaries

It is important to note that menstrual disturbances are not listed as direct side effects of GLP-1 receptor agonists in UK product information

Taken in conjunction with an appropriate diet and exercise regimen, GLP-1s are effective at lowering a persons weight

Large-scale clinical trials are needed to fully understand the effects of GLP-1RAs on ICP, headache outcomes, visual prognosis and quality of life in IIH patients