9 Conclusion The favorable impacts of omega-3 PUFAs on the neurovascular microenvironment indicate their potential to influence neural and immune cells in the brain through various physical and biochemical pathways, leading to outcomes such as anti-inflammatory, anti-nociceptive, antioxidative, and mood regulation
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This is supported by studies using neurons differentiated from patient-derived induced pluripotent stem cells (iPSC), which were found to display hyperexcitability and increased intracellular Ca 2+ levels, as well as increased transcription of genes involved in Ca 2+ -signalling, compared with neurons derived from healthy unaffected controls [19, 20]
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