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Activation by nitroreductase under hypoxia conditions, caused the release of SN38 with high selectivity and cytotoxicity toward biotin-positive tumor cells

S.HanS.et al (2014)

10.1016/j.pharmthera.2013.09.006 162 RynneJ.MosavieM.MasseM

Lipolysis Stimulation The peptide has been shown to stimulate lipolysis - the breakdown of triglycerides stored in adipocytes into free fatty acids and glycerol that can be released into circulation for use as energy by other tissues

Synaptogenesis & dendritic spines Investigated in rodent tissue and cell models for its reported ability to increase dendritic spine density preclinical only, and the primary source assays were retracted in 2025

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