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Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum

Modelling the blood-brain barrier: beyond the endothelial cells

J Biotechnol 10(261):194206 Szczeklik K, Krzysciak W, Domagala-Rodacka R, Mach P, Darczuk D, Cibor D, Pytko-Polonczyk J, Rodacki T, Owczarek D (2016) Alterations in glutathione peroxidase and superoxide dismutase activities in plasma and saliva in relation to disease activity in patients with Crohns disease

It also plays a central role in neutralizing hydrogen peroxide and other harmful substances that build up during normal metabolism or exposure to pollutants

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Published preclinical studies have investigated 5-Amino-1MQ as a selective inhibitor of Nicotinamide N-methyltransferase (NNMT) in laboratory models (Neelakantan et al., 2018)