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Para embarazo planificado, algunos agentes como semaglutida deben suspenderse al menos 2 meses antes de la concepcin planificada [15] [17] Diagnstico de carcinoma medular de tiroides o MEN-2: Contraindicacin para agonistas GLP-1 con advertencia en caja (semaglutida, liraglutida, dulaglutida) [18] [19] Situaciones que justifican cambio de agente: La intolerancia gastrointestinal persistente tras 12 semanas de tratamiento puede justificar cambio a un agonista GLP-1 alternativo con diferente perfil farmacocintico

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10.1161/HYPERTENSIONAHA.110.161505 98 DronavalliS.BakrisG