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Consistent with the compromised function of apoE4, human carriers exhibit increased risk of CAD compared to humans expressing apoE3 or apoE2 (heterozygous) (126,132,133)

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This is incredibly significant, as slow-wave sleep is the exact period when the vast majority of natural GH release occurs

Chronic stress depletes progesterone because high cortisol diverts progesterone production toward stress hormone synthesis instead of reproductive hormone balance